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How does sequence affect function of protein?

Posted on August 22, 2022 by Author

How does sequence affect function of protein?

The unique amino acid sequence of a protein is reflected in its unique folded structure. This structure, in turn, determines the protein’s function. This is why mutations that alter amino acid sequence can affect the function of a protein.

What is the impact of AlphaFold?

AlphaFold DB will facilitate research on evolution of (multi-domain) protein structures and on the relation of structure and function, providing clues on engineering new functions and accelerating synthetic biology applications.

How do scientists determine protein structure?

The most common method used to study protein structures is X-ray crystallography. With this method, solid crystals of purified protein are placed in an X-ray beam, and the pattern of deflected X rays is used to predict the positions of the thousands of atoms within the protein crystal.

How does DNA sequence determine protein structure?

DNA carries the genetic information for making proteins. The base sequence determines amino acid sequence in protein. Messenger RNA (mRNA) is a molecule which carries a copy of the code from the DNA, in the nucleus, to a ribosome, where the protein is assembled from amino acids.

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Does AlphaFold solve the protein folding problem?

AlphaFold 2’s results at CASP were described as “astounding” and transformational. Some researchers noted that the accuracy is not high enough for a third of its predictions, and that it does not reveal the mechanism or rules of protein folding for the protein folding problem to be considered solved.

Can DeepMind’s AlphaFold program predict protein structure?

DeepMind’s program, called AlphaFold, outperformed around 100 other teams in a biennial protein-structure prediction challenge called CASP, short for Critical Assessment of Structure Prediction. The results were announced on 30 November, at the start of the conference — held virtually this year — that takes stock of the exercise.

Can AlphaFold 2 solve a 50-year protein structure challenge?

And then, after three decades of competitions, the assessors declared that AlphaFold 2 had succeeded in solving a challenge open for 50 years: to develop a method that can accurately, generally and competitively predict a protein structure from its sequence (or, well, a multiple sequence alignment, as we will see later).

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Can Google’s AlphaFold 2 predict proteins’ structure?

Google ‘s AlphaFold 2 indisputably won the 14 th Critical Assessment of Structural Prediction competition, a biannual blind test where computational biologists try to predict the structure of several proteins whose structure has been determined experimentally — yet not publicly released.

Can deep learning predict protein structure prediction?

The outstanding performance of AlphaFold 2 in the recent Critical Assessment of protein Structure Prediction (CASP14) experiment demonstrates the remarkable power of deep learning in structure prediction.

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