What is normal ANA range?
ANAs can be found in approximately 5\% of the normal population, usually in low titers (low levels). These people usually have no disease. Titers of 1:80 or lower are less likely to be significant. (ANA titers of less than or equal to 1:40 are considered negative.)
What is ENA profile blood test?
An extractable nuclear antigen (ENA) panel detects the presence of autoantibodies in the blood that react with proteins in the cell nucleus. These proteins are known as “extractable” because they can be removed from cell nuclei using saline and represent six main proteins (Ro, La, Sm, RNP, Scl-70 and Jo1).
How do you read an ANA test?
A positive ANA test is usually reported as both a ratio (called a titer) and a pattern, such as smooth or speckled. Certain diseases are more likely to have certain patterns. The higher the titer, the more likely the result is a “true positive” result, meaning you have significant ANAs and an autoimmune disease.
Is an ANA of 320 high?
If the ANA titre is high (e.g. 1:640, 1:1280 or 1:2560), this indicates more severe disease. If the ANA titre is low (e.g. 1:40, 1:80 or even 1:160), there is often no autoimmune disease. If the ANA titre is in the middle (e.g. 1:320), the result is less clear and should be interpreted in the clinical context.
What is dsDNA and ENA testing?
Autoantibodies to nuclear antigens, i.e. antinuclear antibodies (ANA), antibodies to double-stranded DNA (dsDNA) and extractable nuclear antigens (ENA), are useful as diagnostic markers for a variety of autoimmune diseases.
Why do we test ENA?
The 4-test ENA panel is used to help diagnose mixed connective tissue disease (MCTD), lupus (SLE), and Sjögren syndrome. The 6-test ENA panel can also help identify scleroderma and polymyositis/dermatomyositis.
What does ANA titer 640 mean?
In our laboratory, an ANA titer of 1:640 is defined as a “high titer” because of a 0.5\% prevalence of positives in normal individuals.
What are the different types of Ena tests?
Most ENA blood tests are a 4 test panel that includes Anti-RNP, Anti-Sm, Anti-SS-A, and Anti-SS-B autoantibodies. Depending on the signs and symptoms being experienced, a medical provider may recommend a 6 panel test instead.
What is an anti-ENA panel?
An anti-ENA screen is usually prescribed following a positive result in an antinuclear antibody (ANA) test. While the ANA test suggests the presence of an autoimmune disorder, an anti-ENA panel makes it possible to distinguish between many different collagen diseases. What do the results mean?
What does the ENA blood test detect?
Understanding the ENA Blood Test Results. The extractable nuclear antigen (ENA) blood test helps to detect the presence of autoantibodies that are within the proteins of the nucleus of a cell.