What are the conditions necessary for tautomerism?
Now, the two conditions for tautomerism are: Compounds must have an electron withdrawing atom or group i.e., atom which is more electronegative than carbon and has the tendency to accept the hydrogen atom (as tautomerism involves migration of hydrogen atom).
What is the concept of tautomerism?
Tautomerism is a phenomenon where a single chemical compound tends to exist in two or more interconvertible structures that are different in terms of the relative position of one atomic nucleus which is generally the hydrogen. Tautomerism is also termed as desmotropism.
Does tautomerization stabilize?
The positioning of the carbonyl groups allows for the formation of a stabilizing intramolecular hydrogen bond between the hydroxyl group of the enol and the carbonyl oxygen. The alkene group of the enol tautomer is also conjugated with the carbonyl double bond which provides additional stabilization.
Is tautomerization spontaneous?
Lowdin proposed that the rare tautomeric forms can be produced through the proton transfer within the hydrogen bonds connecting a base pair and it may lead to spontaneous mutation.
What is tautomerism explain with suitable example?
Tautomers are isomers of a compound which differ only in the position of the protons and electrons. Some examples of tautomerism: NOTE: The equilibrium arrows above do not intend to show the position of the equilibrium, only that an equilibrium exists between the two forms.
What is an example of tautomerism?
Tautomerism Example Ketone-enol, enamine-imine,lactam-lactim are some of the examples of tautomers. Meanwhile, some key features of Tautomerism are that this process provides more stability for the compound.
Does Deamination cause Transversion?
Transitions can be caused by oxidative deamination and tautomerization. Although there are twice as many possible transversions, transitions appear more often in genomes, possibly due to the molecular mechanisms that generate them.
What is slippage during DNA replication?
Replication slippage or slipped-strand mispairing involves the misalignment of DNA strands during the replication of repeated DNA sequences, and can lead to genetic rearrangements such as microsatellite instability.